Abstract: Objective To explore the relation between CS₂ exposure and the trace elements of serum copper,serum zinc,serum selenium,provide the basis for the mechanism of toxicity effects of CS₂ on cardiovascular system disease.Methods In filature workshop of a viscose rayon factory we selected 76 workers with age below 45 years old and touchtime to CS₂ beyond 5 years as exposure group;In cotton plasm workshop of the same factory selected 33 workers who once touched CS₂ but now have been kept away from CS₂ more than 5 years as intervention group;and selected 23 workers who had never touched CS₂ as control one,and the epidemiological cross-sectional investigation was carried out.Results SCu,SZn and S Se of exposure group were all lower than control one(P=0.001).In multivariable stepwise regression,we discovered that exposure to CS₂ caused negative contributions on SCu,SZn,and SSe(partial regression coefficients β are separately -10.417,-8.9735 and-15.5098).Conclusion The results suggested CS₂ exposure could reduce the levels of Scu,SZn and S Se.