Abstract: ObjectiveIn order to explore the risk factors of glioma.MethodsWe conducted the 1:2 case-control studies with the conditional logistic regression,98 cases and 196 controls ware investigated with standard questionnaires.ResultsThe results of invariable analysis showed that smoking period over 30 years,history of head trauma,lead exposure,X-ray and family history of tumor have relationship with glioma development,and the results of multi-variable analysis showed that the X-ray,history of head trauma and family history of tumor have close relationship with the development of glioma.ConclusionThe prevention for the Xray damage and trauma should be paid attention,and all the people who have tumor family history should be screened in time.