Abstract: Objective In order to investigate the aetiological factors of upper dig estive tract cancer in Taixing area.Methods On population based a case-control study including 591 cases of esophageal cancer,360 cases of liver cancer,430 cases of stomach cancer newly diagnotised and controls matches with age,sex and resident area was carried out.Results Multiple logistic regression analysis show that common risk factors of upper digestive tract cancer in Taixing Area are higher comsumption of alcohol and related diseases(chronic gastritis,gastriculcer and stomach cancer; pathological change of esophagus and esophageal cancer;chronic hepatitis cir rhosis and liver cancer).Other wise,it was found that increased risk for esophageal cancer was associated with the feel constrained.long-term melancholy,family history of esophagus cancer,like eating salty food and ove-rhot diet,HBsAg positive and family history of liver cancer can increased risk for liver cancer,while risk factors of stomach cancer are feel constrained and longterm melancholy,less eating fresh veg etables.Conclusion It is necessary to prevent such as above risk factors in Taixing Area.