Abstract: Objective To avert the intrauterine lead exposure.Methods Sample collected from pregnant women were detected for lead load body by atom absorption spectrum.The intervention epidemiological toward the persons who were voluntary body was conducted by Ebselen.Results The 38th weeks intervention group increased 21.5%,obviously lower than the control group(64.5%),zinc contentsand(GSH-Px)activites were incresed,LPO contents the difference was very significant(P_ar<0.01).Conclusion It points out that Ebselen has counteract effect on pregnancy lead load,the Selenium in Ebselen does not take part in the reser ve but enhancese the activity of GSH-Px,facilitates the reserve of zinc.There is the probability that Ebselens availability to prevent the infants lead poisoning.