Abstract: Objective This study is part of an effort to develop effective prevention for hyperlipidemia.Methods Four groups of wistar male rats were fed a high fat diet for four weeks to induce hyper lipidemia.One group was fed normal diet as control.Three groups that fed the high fat diet were administrated with celery extract at the doses o f 1.05g/kg·bw、0.35g/kg·bw、and 0.18g/kg·bw respectively.At the middle and the end of the experiment,the contents of seum total cholesterol(TC)、triglyceride (TG)and high density lipopro tein cholesterol(HDL-C)were determined.Results At the end of the experiment,a significant reduction was found in the serum TC and TG of the animals treated with celery extracts at the high and middle doses.In the high dose group TC and TG were decreased 24.2% and 35.1% respectively.But there was no different changes of HLD-C content.Conclusion There were regulation effects of celery extract on lipid parameters of rats fed a high fat diet.