Abstract: ObjectiveTo study the effect of hypoxia envioment on the content of AVP in brain center of rat.Methods To move the standardized healthy male wistar rats to high altitude environment(2 260m and 3 460m above sea level)from plain(5m above sea level),and used analytic method of RIA to study the change of content of AVP in hypophysis and other parts of rat's brain during the period of acute hyposia(24h)and slow hypoxia (30d).Results(1)During the period of acute hypoxia(2 260m above sea level),compared with the plain contrast group,the content of AVP in rat's pons-oblongata increased(P>0.05),in other 7 brain areas significantly decreased(P<0.01),parts of brain(P<0.05);(2)During the period of acute hypoxia(3 460m above sea level),the content of AVP hypophysis increased(P<0.05)and pons-oblongata increased(P<0.01,hippocampus P<0.05);(3)During the period of slow hypoxia(3 460m above sea level,30d),the content of AVP showed a mobile change that connected with time:increasing-decreasing-increasing(parts of brain),and has significant sense of statistic(P<0.01).ConclusionAfter the rats were moved to high altitude environment, both acute hypoxia and slow hypoxia can affect the excreting and releasing of AVP in brain center,AVP takes part in the course of stress reaction and the regulation of adaptable ability,it may be act as regulator and modulator through neuro-humoral cycle in the course.