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张扬, 陈坤, 张海蕾, 朱益民. 非吸烟女性肺癌发病危险因素的Meta分析[J]. 中国公共卫生, 2001, 17(10): 869-870. DOI: 10.11847/zgggws2001-17-10-05
引用本文: 张扬, 陈坤, 张海蕾, 朱益民. 非吸烟女性肺癌发病危险因素的Meta分析[J]. 中国公共卫生, 2001, 17(10): 869-870. DOI: 10.11847/zgggws2001-17-10-05
ZHANG Yang, . Meta-analysis of Risk Factors of Lung Cancer on Never-smoking Female[J]. Chinese Journal of Public Health, 2001, 17(10): 869-870. DOI: 10.11847/zgggws2001-17-10-05
Citation: ZHANG Yang, . Meta-analysis of Risk Factors of Lung Cancer on Never-smoking Female[J]. Chinese Journal of Public Health, 2001, 17(10): 869-870. DOI: 10.11847/zgggws2001-17-10-05

非吸烟女性肺癌发病危险因素的Meta分析

Meta-analysis of Risk Factors of Lung Cancer on Never-smoking Female

  • 摘要: 目的 综合评价我国非吸烟女性肺癌发病的危险因素.方法 应用Meta分析方法对国内6个有关非吸烟女性肺癌危险因素的病例对照研究进行定量综合分析,共累积病例915例,对照1321例.统计处理采用Meta分析的随机效应模型.结果 肺部疾病史、家族肺癌史、油烟污染、煤烟污染、被动吸烟等5个研究因素的合并OR值分别是2.87、2.79、2.51、1.42和1.29,进一步分层研究显示随着油烟污染程度的加重,其OR值也有明显的上升.结论 家族肺癌史、肺部疾病史、油烟污染、煤烟污染等因素可能与非吸烟女性肺癌的发生有关,被动吸烟的作用尚不能肯定.

     

    Abstract: Objective To evaluate the risk factors of lung cancer in Chinese never-smoking women.Methods The results of 6 case-control studies from 1990 to 1999 were analyzed by Meta-analysis method in this study.The cumulative cases and controls were 915 amd 1321,respectively.Der Simonian and Nan Laid model were applied to process data.Results The pools OR values of family history of lung cancer,personal history of non-neoplastic lung disease,cooking oil fume,coaly pollution and environmental tobacco smoking(ETS)exposure were 2.87,2.79,2.52,1.42 and 1.29 respectively.Therefore,family history of lung cancer and personal history of non-neoplastic lung disease may be the most important risk factors of female lung cancer in China.Conclusion There was also significantly positive relationship between female lung cancer and the degree of cooking oil fume pollution or coaly pollution.The effect of exposure to ETS on lung cancer was uncertain in this study and further investigation was needed.

     

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