Abstract: ObjectiveTo study comparatively repairing function of gynostemma on damaged genetic mater ial by pentaphyllum potassium aluminum sulfate or CP.MethodsThe micr onucleus assay in mice marrow PCEand chr omosome aberration assay in mice marrow cells are used.Results(a)The feed containing 10% g ynostemma makes the rate of micronucleus decline from (9.00±1.83)j to(3.80±0.79)j(P<0.001)and the rate of chromosome aberration decline from(13.60±2.22)j to (5.30±1.34)% (P<0.001)by petaphyllum potassium aluminum sulfate.(b)The feed containing 10% g ynostemma makes the rate of micro nucleus decline from(33.00±4.45)j to(19.90 ±2.60)j(P<0.01)and the rate of micronucleus decline(25.9±3.07)% to(13.60±2.22)% (P<0.01)by CP.ConclusionInhibitory rates of gynostemma to micronucleus rates and aberration rates by pentaphyllum potassium aluminum sulfate are bigger t han by CP,the inhibitory rate of gynostemma to genetic material damag ed by potassium aluminum sulfate is bigger than by CP(P<0.001).