DEHP对大鼠脂质过氧化反应的影响

Effect of DEHP on Lipid Peroxidation in Rats

摘要: 目的探讨DEHP对大鼠脂质过氧化反应的影响.方法通过对不同剂量DEHP染毒大鼠的血液、肝组织匀浆、线粒体匀浆中GSH-Px、GST、SOD、MDA指标的测定.结果随着DEHP染毒剂量的增加,大鼠血中、组织中的GSH-Px、GST、SOD活性降低,MAD含量增加,尤其是大剂量组,差异均有显着性(P<0.05,P<0.01).结论DEHP可明显增加大鼠体内的脂质过氧化反应.

Abstract: ObjectiveTo oberve the effect of DEHP on lipid peroxidation in rats.MethodsThe changes of GSH-Px GST、SOD and MDA in the tissues of blood and liver of rats that given different doses of DEHP were detected.ResultsGSH-Px、GST and SOD in the blood and liver dramatically decreased with the increase of DEHP.But MDA content significantly increased,especially in high dose of DEHP.ConclusionDEHP can significantly increase lipid peroxidation in rats.