α-亚麻酸对大鼠行为、视网膜及肝脑脂肪酸构成的影响

Effects of α-linolenic Acid on Rats’ Behavior, Retina and Liver, Brain Fatty Acid Composition

摘要: 目的研究α-亚麻酸对第二代大鼠学习记忆、视网膜发育及肝、脑脂肪酸构成的影响.方法利用全合成饲料对Wistar大鼠进行两代喂养,以Morris水迷宫、视网膜电位测定仪及气相色谱仪进行第二代大鼠学习记忆、视网膜电位及肝、脑脂肪酸构成分析.结果 α-亚麻酸(苏子油)能够促进大鼠的脑、视觉发育,提高仔代大鼠的学习记忆能力和视网膜电位;在生化方面提高了肝总脂中C_18:3、C_20:5和脑总脂中C_22:6的百分含量;α-亚麻酸缺乏(茶油)将对脑、视觉发挥正常功能造成不利影响.结论 α-亚麻酸(苏子油)对脑和视网膜具有较高的营养生理作用.

Abstract: Objective The second generation rats were used to study the effect of-linolenic acid on memory,retina and brain,liver fatty acid composition.Methods Based on the Morris Water plaza,ERG equipment and gas chromatog raphy,the second generation rats were analyzed.Results α-linolenic acid(per illaoil)could promote brain and retina development,elevate the learning ability and the electroretinalgraphic amplitudes,elevate the learning ability and the electroretinalgraphic amplitudes,increase the percent of C_18:3、C_20:5 in liver total fatty acids and C_22:6 in brain total fatty acids:-linolenic acid deficieny impair spatial learning and visual funct ion.Conclusion -linolenic acid(perilla oil)had important nutritional value.