Abstract: Objective To explore the prevalence of hepatitis G virus(HGV)infection and its risk factors among the general population in Shenzhen.Methods According to the cluster sampling,1843 subjects were selected randomly and tested for anti-HGV in sera by ELISA,and the samples which the anti-HGV were positive were further tested for HGVRNA using RT-PCR.Results The prevalence rate of anti-HGV was 9.33% in the population.The prevalence rate of HGVRNA was 2.33%(2.45% for male and 2.20% for female,respectively).There was no significant difference between different age groups.The histories of hepatitis,surgical dental operations and injections were not associated with HGV infection.Hepatitis B vaccination and positivity of HBsAg,anti-HBs and anti-HBc were not related to anti-HGV and HGVRNA prevalence rate.However,It was higher in middle school students and teachers than other professional groups.Conclusion The prevalence of HGVRNA seemed to be high among the general population in Shenzhen.The risk factors of HGV infection in the population needed to be further studied.