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孙桂菊, 王少康, 蒋兆坤, 詹永红, 浦跃朴, 黄杰, 王盛良, 周自新. 富铬豆芽粉对糖尿病小鼠血糖调节作用的研究[J]. 中国公共卫生, 2002, 18(4): 449-450. DOI: 10.11847/zgggws2002-18-04-45
引用本文: 孙桂菊, 王少康, 蒋兆坤, 詹永红, 浦跃朴, 黄杰, 王盛良, 周自新. 富铬豆芽粉对糖尿病小鼠血糖调节作用的研究[J]. 中国公共卫生, 2002, 18(4): 449-450. DOI: 10.11847/zgggws2002-18-04-45
SUN Gui-ju, WANG Shao-kang, JIANG Zhao-kun, . Study on Regulation of Bean Sprout Powder Rich in Chromium to Alloxan Diabetes Mice[J]. Chinese Journal of Public Health, 2002, 18(4): 449-450. DOI: 10.11847/zgggws2002-18-04-45
Citation: SUN Gui-ju, WANG Shao-kang, JIANG Zhao-kun, . Study on Regulation of Bean Sprout Powder Rich in Chromium to Alloxan Diabetes Mice[J]. Chinese Journal of Public Health, 2002, 18(4): 449-450. DOI: 10.11847/zgggws2002-18-04-45

富铬豆芽粉对糖尿病小鼠血糖调节作用的研究

Study on Regulation of Bean Sprout Powder Rich in Chromium to Alloxan Diabetes Mice

  • 摘要: 目的 观察富铬豆芽粉对糖尿病小鼠的血糖调节作用.方法 用40mg/kg的CrCl3溶液一次性浸泡绿豆24小时,在25℃发芽5天获得富铬豆芽,60℃干燥至水分含量低于11%,粉碎得富铬豆芽粉样品,总铬含量为72.6mg/kg,铬有机化程度达95%左右.对其毒性和对四氧嘧啶高血糖模型小鼠的血糖调节作用进行研究.结果 所研制的富铬豆芽粉小鼠经口LD50>10000mg/kg·bw,属无毒级,骨髓微核、精子畸形试验表明无突变效应.给四氧嘧啶高血糖模型小鼠3个剂量的富铬豆芽粉(按其总铬含量计):低剂量组8.3μg/kg·bw/d、中剂量组16.67μg/kg·bw/d、高剂量组33.33μg/kg·bw/d,灌胃30天后,中剂量组和高剂量组动物空腹血糖值、血糖降低的绝对值与对照组比较有显著性差异(P<0.05),而低剂量组与对照组无显著性差异(P>0.05).结论 富铬豆芽粉具有降低糖尿病小鼠血糖的作用,值得进一步研究开发利用.

     

    Abstract: Objective To study the reducing blood glucose action of the bean sprout powder rich in chromium on the alloxan diabetes mice.Methods Mung bean was dipped in the culture containing 40mg/kg CrCl3 for 24 hours and then was germinated under 25℃ for 5 days.The bean sprout was dried under 60℃ until the content of water in the bean sprout became lower than 11%.The dried bean sprout was crushed into powder.The total chromium content in the bean sprout powder was 72.6mg/kg and the rate of organic chromium was 95%.This bean sprout powder was given the alloxan diabetes mice by gav-age.Results The LD50 of Kunming mice of the bean sprout powder was higher than 10000mg/kg·bw and the bean sprout powder was testified with no mutagenesis.The alloxan diabetes mice was given three doses of the bean sprout powder by gav-age for 30 days.According to the total chromium content the three doses were low dose group,8.3μg/kg·bw/d,medium dose group,16.67μg/kg·bw/d,.and the high dose group 33.3μg/kg·bw/d.The results indicated that the fasting blood glucose levels and the absolute reducing blood glucose values of the medium and high dose groups were significantly lower than control group (given water by gavage,P<0.05).And there were no significant differences between the low dose group and the control group(P>0.05).Conclusion The bean sprout powder rich in chromium can reduce the blood sugar of the diabetes mice.

     

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