Abstract: ObjectiveTo investigate the effect of zinc and vitamin E on oxidation and nonenzymatic glycation in diabetic rats induced by STZ.MethodsDiabetic rats were supplemented with Zn and/or VE.Six weeks later,blood glucose,serum insulin activity,serum MDAcontent,GHb level and SOD,GSH-Px activity were determined.ResultsCompared with DM control group,blood glucose,MDA and GHb levels decreased and serum insulin,SOD,GSH-Px activity increased in Zn and/ or VEsupplemented group.Joint supplementation of Zn and VE had apparent effect.ConclusionZn and VEcould effectively inhibit the oxidation and nonenzymatic glycation as well as enhance the antiox idation capacity in diabetic rats,exer ted favourable effects against the occur rence and development of chronic complications in diabetic mellitus.