Abstract: ObjectiveTo study the preventive and health effects of p yracantha on cardio vascular disease.MethodsFour groups of Wistar rats were fed respectively with standard diet,85% standard diet plus 15% pyracantha,high fat diet,85% high fat diet plus 15% pyracantha.Ten weeks later,the Plasma TC,TG,HDL-C,LDL-C,apoA,apoB.whole blood viscosity,plasma viscosity,and hematorcrit were determinated while plasma fibrinogen and inhibited erythrocyte ag gregation were calculated,and serum creatine kinase(CK),creatine kinase isoenzyme MB(CK-MB),lactic dehydrog enase(LDH),and A-hydroxybutyric acid dehydrogenase(HBDB)were measured too.ResultsAt the end of the experiment,the plasma HDL-Cand apoA levels of pyracantha groups were significantly higher than that of control groups,while the ratios of apoB/apoA were significantly lower than that of control groups.Pyracantha decreased TC,TG,the whole blood viscosity,plasma viscosity,plasma fibrinogen,inhibited erythrocyte aggregation and the activities of myocardial enzymes.ConclusionPyracantha could significantly improve the lipoprotein metabolism and the hermorr heology,decreased blood lipids of rats fed with high fat diet,and protected myocardial cell.There were preventive and health effects of pyracantha on car diovascular disease.