Abstract: ObjectiveTo observe the changes of cochlear blood flow(CBF)in guinea-pigs between 654-2 prevention treatment groups and the damaged groups in different times after noise exposure.The changing trend of CBF and the effect of 654-2 on the CBF after noise exposure were discussed.MethodsGuinea-pigs were distributed into three groups:contorl group,damage group,and prevention-treatment group(654-2 group).The Laser-Doppler blood meter was applied to observe the change of CBF in differnet periods after noise exposure.ResultsThe CBF of each group reduced obviously on the 15th hour after noise exposure.Afterwards,they recovered gradually.The CBF of 654-2 group recovered primarily on the third day after noise exposure.While,the CBF of the damage group didn't recover until the seventh day.Conclusion6542 can impr ove the CBF of cochlear,can prevent and treat noise-induced hearing damage in certain degree.