Abstract: ObjectiveTo investigate the intervention method and effect of STD/AIDS healthy education to the high risk female suspected prostitution in public situation along highways and to professional driver,and comelated evaluation the knowledge structure between previous two groups.MethodsTo select the two groups which is high risk female and truck drivers along the highways of Shenzhen,to intervene with series STD/AIDS healthy education and take STD/AIDS knowledge questionnaire investigations before and afier the intervention respectively and comelated analysis of disease status between two groups.ResultsBefore and after the healthy education intervention,the scores are different significantly between and in two groups(P<0.01).Through the healthy education intervention,the cognitions about STD/AIDS knowledge,the route of transmission and safe sexual behavior are improved markedly.Many markers before and after intervention are different obviously(χ² test:P<0.05,P<0.01).In last two years,questionnaire retrospective studies of STD/AIDS disease status in driver group and high risk female group indicate the prevalence rate and KAP knowledge have obvious comelation(r=0.82).Conclusion1.The effect of STD/AIDS healthy education intervention to high risk people is obvious.2.The driver group and high risk female group are interacted in STD/AIDS knowledge and prevalence rate.