Abstract: ObjectiveTo discuss risk factors of premature coronary heart dirsease.MethodsA case-control study was conducted in investigating the risk factors of coronary heart disease(CHD).Participants were divided into three groups,premature coronary heart disease(groupⅠ);premature control(groupⅡ),and elderly control groups(groupⅢ).Each group had 60 people.ResultsCompared with the groupⅡ,odds ratio(OR)of family history of CHD,cigarette smoking,hypertension were 2.17,1.93,1.42,when compared with group Ⅲ,OR of cigarette smoking,family history of CHD and hypertension were 2.28,2.68,2.07 respectively.Means of cigarette smoking each day in groupⅠwas significantly higher than that of two groups.Multiple variables analysis indicated that variables being selected into Logistic equation in former analysis were physical exercise,family history of CHD and number of cigarettes each day and in latter analysis were history of hypertension, family history of CHD and hypertension,which maybe the risk factors of premature coronary heart disease.ConclusionIt was significant to control smoking,weight and blood pressure of premature,especially those with positive family history.