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龚健, 罗东, 刘景晔, 李荣成, 王鹏富, 黄全诚, 杨进业, 徐志一. 国产甲肝减毒活疫苗(IA-1株)与进口甲肝灭活疫苗的2年免疫效果比较[J]. 中国公共卫生, 2002, 18(12): 1412-1413. DOI: 10.11847/zgggws2002-18-12-02
引用本文: 龚健, 罗东, 刘景晔, 李荣成, 王鹏富, 黄全诚, 杨进业, 徐志一. 国产甲肝减毒活疫苗(IA-1株)与进口甲肝灭活疫苗的2年免疫效果比较[J]. 中国公共卫生, 2002, 18(12): 1412-1413. DOI: 10.11847/zgggws2002-18-12-02
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GONG Jian, LUO Dong, LIU Jing-ye, . Comparison of Two-year Follow-up Immunogenicity Between Live Attenuated Hepatitis A Vaccine and Imported Inactivated Vaccine[J]. Chinese Journal of Public Health, 2002, 18(12): 1412-1413. DOI: 10.11847/zgggws2002-18-12-02
Citation: GONG Jian, LUO Dong, LIU Jing-ye, . Comparison of Two-year Follow-up Immunogenicity Between Live Attenuated Hepatitis A Vaccine and Imported Inactivated Vaccine[J]. Chinese Journal of Public Health, 2002, 18(12): 1412-1413. DOI: 10.11847/zgggws2002-18-12-02
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国产甲肝减毒活疫苗(IA-1株)与进口甲肝灭活疫苗的2年免疫效果比较

Comparison of Two-year Follow-up Immunogenicity Between Live Attenuated Hepatitis A Vaccine and Imported Inactivated Vaccine

    摘要
  • 摘要: 目的 比较国产甲肝减毒活疫苗和进口甲肝灭活疫苗免疫效果.方法 在广西柳城县筛选出6～12岁甲肝易感儿童217人,以个体随机分为4个组.B、C组接种国产甲肝减毒活疫苗(LA-1株,滴度106.75TCID50),接种程序分别为0-6和0-12;D组接种低滴度国产甲肝减毒活疫苗(LA-1株,滴度106.0TCID50),E组接种史克公司市售甲肝灭活疫苗(贺福立适,720E1.U),接种程序均为0-6.各组于第1针免后1,6,12,24个月,第2针免后1个月采血,用美国ABBOTT公司的ImxmEIA试剂,检测甲肝抗体IgG.结果 滴度106.75TCID50的国产减毒活疫苗两种程序,除0-6程序组在第2针免后1个月的抗体水平峰值较低外,其余各次随访的抗体反应结果均与进口甲肝灭活疫苗相似.低滴度减毒活疫苗(106.0TCID50)的抗体阳性率和抗体水平均低于其他各组.结论 滴度106.75TCID50国产甲肝减毒疫苗与进口甲肝灭活疫苗免疫效果相近,具有良好的免疫原性和很好的回忆反应,加强免疫可以提高疫苗的保护效果和延长保护年限.

     

    Abstract: Objective To compare immune efficacy of live attenuated hepatitis A vaccine with that of inactivated vaccine.Methods These 217 children aged 6-12 years with negative anti-HAVIg G at the enrollment from Liucheng county of Guangxi Zhuang autonomous region were randomized into 4 groups.Groups B and C received the LA-1 strain,a live attenuated HAV vaccine(106.7550,Changchun Institute of Biology Products)according to schedules of 0-6 months and 0-12 months respectively.106.0TCID50 live attenuated HAV vaccine was administered to group D,and inactivated hepatits A vaccine(HavrixTM,720 E1.U,SKB)to group E both at 0,6 month follow-up bloods were taken at month,6,12,24 after the first dose and 1 month after the second dose for all groups with additional samples at month 1 for Group D and E.All samples were tested for anti-HAVIg G using Imx mEIA kit(Abbott Lab.).Results During follow-up,in both schedules,live attenuated vaccine had similar effective seroconversion rates and antibody titers as inactivated vaccine at all points of time except for that of the 0-6 months schedule at 1 month after the booster.In group D with lower dose live attenuated vaccine,the anti-HAV positive rate and level were lower than those in the other groups.Conclusion A high dose of attenuated live HAV vaccine with a booster dose was similar to the inactivated vaccine in immunity effect,demonstrating a good immunogenicity and memory.Booster dose will ensure long-term protection against HAV.

     

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