Abstract: Objective To comprehend metabolism of iodine nutrition of women during pregnant stage and breast-feed stage.Methods To collect urine and salt of women during pregnant stage(12-14 weeks and 18-22 weeks) and mothers and hers newborns during breast-feed stage.To use method for determination of iodine in urine by As(Ⅲ)-Ce⁴⁺ catalytic spectrophotometry to measure urine iodine.Results Urine iodine of 130 early pregnant women decreased rapidly.There were statistical significant differences between early stage pregnant women and 120 non-pregnant women and mid-pregnant stage women(P<0.01),but urine iodine content <100μg/L was 13.3%,urine iodine increased 718.0μg/L(M) during breast-feed stage,urine iodine content >1 000μg/L was 21%,urine iodine content of newborns >800μg/L was 41.0%.Correlation was found between milk iodine of mother and urine iodine of new borns in pregnant group(r=0.211,P<0.05).The above changes in countryside weren't outstanding.Conclusion To replenish iodine in pregnancy should start early,salt iodine was little,and it was diversified in form.The density of salt iodine should be decreased in order to prevent endangerment of high iodine.