Abstract: Objective To explore the effect of iron against the toxicity of lead and compare the lead exclusion effects of several iron fortifiers.Methods Random design method was employed and before the study fifty-six Wistar rats were randomly divided into seven groups including blank control group,negative control group,positive control group,ferrous sulfate(FeSO₄)group,ferrous lactate(C₆H₁₀ FeO₆)group and two level(high,low)sodium iron ethylenediaminetetraacetate(NaFe EDTA)groups.Except the blank control group which only received double distilled water treatment throughout the experiment all the other rats were treated with lead solution.Four weeks later except for the blank and model control groups the other five groups were treated with DMSA,FeSO₄,C₆H₁₀ FeO₆ and two level NaFe EDTA(high,low)solutions respectively at the same time.Eight weeks later when the study was finished the blood lead level was determined.Results The blood lead levels of high and low level NaFe EDTA groups were significantly lower than that of model control group,and the relative reducing level of blood lead in high level NaFe EDTA group was higher than those of FeSO₄ group and C₆H₁₀ FeO₆ group significantly.Conclusion Iron can counteract the lead toxicity and the effect of NaFe EDTA reducing the blood lead was the best among the three kinds of iron fortifiers.