Abstract:
Objective To explore the association between polymorphism of angiotensin-converting enzyme(ACE)gene and hypertension in Mongolian people.
Methods On the basis of prevalence survey, fifty-one hypertensives with family history of hypertension, sixty-four hypertensives without family history of hypertension, thirty-two normotensives with family history of hypertension, eighty-five normotensives without family history of hypertension were selected as subjects in J une 2001, and polymerase chain reaction(PCR)technique was used to examine the insertion/deletion polymorphism of ACE gene.χ2 test was used to compare the differences of I/D polymorphism genetypes frenqency and I/D allele frequency among the four groups.
Results There was no significant difference in frequency of ACE genetypes(II/D/DD)among these four groups(P > 0.1).Frequency of ID genetype is the highest, then that of II genetype and frequency of DD genetype was the lowest in the all groups.There was also no significant difference in frequency of I and D allele among these four groups.There was a similar phenomenon that frequency of I allele was higher than that of D allele in the all groups.
Conclusion The I/D polymorphism of ACE gene was not related to hypertension in Mongolian people.
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