除草剂2-甲-4氯苯氧乙酸对小鼠的毒作用

赵淑华; 李景舜; 隋春生

doi:10.11847/zgggws2003-19-04-24

除草剂2-甲-4氯苯氧乙酸对小鼠的毒作用

Poisonous effect of 2-methel-4-chlorophenoxyacetic acid in mice

摘要

摘要:
目的观察2-甲-4氯苯氧乙酸(MCPA)对小鼠内分泌等功能的毒性作用.
方法分别以剂量为20、100、200mg/kg的MCPA给小鼠灌胃, 测定小鼠的体重, 血清中的T ₄、TSH、胆固醇的含量以及脾的脏器系数.
结果染毒17d后, 雄性小鼠各染毒组体重增长速度减缓, 高剂量组未见增加; 雌性小鼠随染毒剂量的增加和染毒时间的延长, 体重明显下降.血中的T ₄含量在低剂量组明显升高, 而高剂量组明显下降; 中、高剂量组血清中TSH明显下降, 而胆固醇的含量明显上升; 脾的脏器系数在中、高剂量染毒组明显下降.
结论 MCPA可干扰甲状腺素的正常代谢, 使胆固醇含量增加, 脾萎缩, 限制小鼠的体重增长, 雌性小鼠较雄性小鼠更为敏感.

Abstract:
Objective To observe the interferring effect of 2-methyl-4-chlorophenox yacetic acid(MCPA)in mice.
Methods Three treated groups are divided by three dosage of MCPA(20, 100, 200 mg/kg, P.O).The weight, T ₄, TSH, cholesterol, the coefficient of spleen are analyzed.
Results After 17 days, the weight of every treat group are significantly lower than the control groups in the male mice, and the weight decreases with the increasing of the doses in the female mice.Among high-or(and)middle-dose group, TSH in blood and coefficient of spleen are significantly lower, but the content of cholesterol in blood increases compared with other treated gropus and control group.The content of T ₄ in blood is abnormal significantly among low, high-dose groups.
Conclusion MCPA can result in obstruction of mice growing, interruption of endocrine, the wither of spleen.The changes of every indexin female is more sensitive than male.

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