先天性小儿脑瘫发病危险因素病例对照研究

邱洪斌; 汪志国; 王保来; 鲁向锋; 王滨有

doi:10.11847/zgggws2004-20-05-06

先天性小儿脑瘫发病危险因素病例对照研究

Case-control study on risk factors of childhood cerebral palsy

摘要

摘要:
目的探讨小儿脑瘫的发病危险因素。
方法对103例脑瘫患儿及206例对照进行以医院为基础的1: 2配比病例对照研究, 所获数据采用条件Logistic回归分析。
结果单因素分析提示, 母亲职业、母亲既往异常产史、孕期鱼及海产品摄入少、孕期母亲贫血、孕妇产前低热、胎儿早产、低出生体重、apgar评份偏低、新生儿期患病、特别是新生儿窒息和颅内出血与小儿脑瘫的发生有关联。多因素分析结果显示, 母亲职业、早产、新生儿窒息为其发病的主要危险因素。
结论本研究结果提示, 脑瘫发病的相关危险因素主要集中在孕期和围产期, 积极预防和消除各种致病危险因素, 可降低脑瘫的发病率。

Abstract:
Objective To indentify possible risk factors of cerebral palsy(CP)in children.
Methods A hospital-based 1: 2 matched case-control study was carried out in 103 children with CP and 206 controls individually matched for sex and age were selected for each case. The data were analyzd by conditional Logistic regression.
Results Eleven risk factors were suggested from univariate analysis, namely mother occupation, abnormal perinatal history, maternal malnutrition and anemia during pregnancy, premature birth, lower birth weight, lower apgar score, neonatal diseases. The risk factors confirmed by multivariate analysis were mother occupation, premature birth, neonatal asphyxia.
Conclusion Relevant risk factors of CP could be seen primarily in gestational and perinatal periods. Their prevention could reduce the incidene of cerebral palsy.

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