依布哂啉对酒精致大鼠过氧化损伤的抑制效果

张静; 张红宇; 林凯; 赵美英

doi:10.11847/zgggws2004-20-05-33

依布哂啉对酒精致大鼠过氧化损伤的抑制效果

Restraining effect of ebselen on peroxidizing damage caused by alcohol to rat

摘要

摘要:
目的了解合成的依布哂啉(Ebs)对过氧化损伤的抑制效果。
方法用5.0g/(kg·d)酒精及Ebs0.5~25.0g/(kg·d)给大鼠灌胃, 于第3周末及第6周末各观察1次血浆谷胱苷肽过氧化物酶(GPx)活性和血清脂质过氧化物(LPO)含量及比值。
结果与酒精组比较, 第3周末5.0mg/(kg·d)以上Ebs组GPx活性增高和LPO含量减少, 第6周末0.5mg/(kg·d)及以上组GPX活性和LPO含量变化均呈极显著剂量反应关系(P均 < 0.01), GPx与LPO比值上升明显。
结论合成的Ebs具有抗氧化损伤的抑制作用, 其有效剂量为5.0mg/(kg·d)(3周)和0.5mg/(kg·d)(6周)。

Abstract:
Objective To realize the restraining effect of the synthesized ebselen(Ebs)on the peroxidizing damage.
Methods 5.0 g/(kg·d)of alcohol and 0.5-25.0 mg/(kg·d)of Ebs were given to the rats'stomach, and the activity of the glutathione peroxidase(GPx)in blood plasma and the amount of the lipid peroxide(LPO)in blood serum and the ratio were observed one time respectively at the end of the third week and the sixth week.
Results Compared with the alcohol group, the GPx's activity of the Ebs group whose dose was over 5.0 mg/kg increased and the amount of LPO decreased at the end of the third week, the GPx's activity of the Ebs whose dose was over 5.0 mg/kg and the change of the amount of LPOgroup had the dose-response relatio n significantly at the end of the sixth week, the ratio between the GPx and LPO increased apparently.
Conclusion The synthesized Ebs can restrain the oxidizing damage, and the effective dose was 5.0 g/(kg·d)of Ebs(3w)and 0.5 g/(kg·d)of Ebs(6 w).

HTML全文

参考文献(9)

施引文献

资源附件(0)