不同水质致突变性分析

Analysis on genotoxicity of different water

摘要:
目的探讨N市水质的致突变性.
方法应用XAD-2大孔树脂吸附浓集水中有机物的技术, 结合Ames试验、微核试验、小鼠精子畸形试验, 研究N市主要水厂水源水、滤池出水、氯化消毒自来水中非挥发性有机物(NOCs)的致突变性.
结果氯化消毒自来水微核率和精子畸形率显著高于阴性对照组(P < 0.05), 氯化消毒自来水5L/皿剂量下, TA98S9MR=4.92, TA98+S9MR=2.69.
结论氯化消毒自来水有一定程度致突变性, 水源水、滤池出水未检出致突变性.

Abstract:
Objective To study the mutagenicity of the water in Ncity.
Methods XAD 2 resin was used to extract the organic atter in water.Ames test, the micronucleus assay and the sperm morphologic test were used to analyze the utagenicity of the nonvolatile org anic copounds(NOCs)in water, for the main waterwor ks sour ce water, the clarified filtration waterand the chlouinated tap water in Ncity.
Results The chlouinated tap water micronucleus rate and seed defor mity rate were sig nificantly higher than those in normal group(P < 0.5).When the chlouinated tap water dosage was 5 L/plate, TA98 S9 MR=4.92, TA98+S9 MR=2.69.
Conclusion Mutagenicity was determined by the chlorinated tap water in some degree, but mutagenicity was not found in the source waterand the clar ifying fillration water.