住院肝炎患者病毒检测及重叠感染状况分析

张涛; 高眉扬; 赵琦; 曹海俊; 徐飚; 姜庆五

doi:10.11847/zgggws2005-21-04-26

住院肝炎患者病毒检测及重叠感染状况分析

Analysis on classification of hepatitis patients and superinfection condition

摘要

摘要:
目的了解上海地区以往肝炎患者的肝炎型别和重叠感染状况.
方法采用ELISA法对从复旦大学公共卫生学院血清库中抽取的上海某区医院90年代初期肝炎患者的血清进行HAVIgM、HCVIgG、HEVIgM和HEVIgG的检测.
结果在上海1143名肝炎患者中, HAVIgM、HBV、HCVIgG、HEVIgM和HEVIgG的阳性率分别为52.1%, 53.6%, 1.3%, 17.8% 和70.4%, 有多重感染的患者数为746人, 约占总病例数的65.4%, 其中甲、乙、丙、戊型肝炎的重叠感染率分别为61.4%, 69.3%, 0.9和17.4%.
结论肝炎患者的多重感染情况普遍存在, 甲乙型重叠感染可能影响乙型肝炎病毒感染的复制, 对健康的危害较为严重.

Abstract:
Objective To investigate the classification of hepatitis patients and the condition of super infection.
Methods The sera came from sera bank of School of Public Health, Fudan University, and all of the hospitalize hepatitis patients in shanghai in 1990 s were determined by ELASA foranti HAVI gM, anti HCVIgG, anti HEVI gMand IgG.
Results In the 1 143 patients, the positive rate of HAVI gM, HBV, HCVIgG, HEVIgMand HEVIgG were 52.1%, 53.6%, 1.3%, 17.8% and 70.4% respectively.And the superinfection patients came up to 746, about 65.4%.The superinfection rates of hepatitis A, B, C, E respecifically equal to 61.4%, 69.3%, 0.9 and 17.4%.
Conclusion The superinfection is very common amongthe hepatitis patients.The interaction of HAV and HBV may restrain the replication of HBV and people health is threatened.

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