酞酸酯对果蝇生存天数影响及其遗传毒性

Effect of phthalic acid ester on drosophila's life span and its mutagenesis

摘要:
目的探讨邻苯二甲酸二丁酯(di-n-butylphthalate, DBP)和邻苯二甲酸二辛酯(di-n-octylphthalate, DOP)对果蝇生存时间的影响和遗传毒性.
方法用等质量混合的DBP和DOP对果蝇经口联合染毒, 采用果蝇寿命试验和果蝇伴性隐性致死试验观察DBP、DOP对果蝇生存时间的影响对生殖细胞的致突变作用.
结果从0.2% 浓度组开始, 果蝇平均寿命与对照组相比差异有统计学意义, 600, 1800mg/L浓度组果蝇突变率与对照组相比差异有统计学意义.
结论 DBP、DOP干扰了果蝇正常的生长发育和新陈代谢, 并加速其衰老; DBP、DOP对果蝇生殖细胞有致突变作用.

Abstract:
Objective To study the influence of phthalic acid esteron drosophilas life span and mutagenesis to drosophi las germ cell.
Methods In drosophilas life span test and SLRL flies were fed with din butylphthalate(DBP)and dinoctyl phthalate(DOP)of identical concentration.
Results Above concentration of 0.02% group flies life span became obviously shor ter compared with the control group; mutation rate of flies in 600, 1.800 mg/L group remar kably differed from that of the control group.
Conclusion DBP and DOP inter fered flies natural development and metabolism, shortened flies life span obviously; DBP and DOP also had mutagenic effect on Droso philas ge m cell.