N-乙酰基转移酶基因多态性与肺癌易感性关系

梁戈玉; 浦跃朴; 尹立红

doi:10.11847/zgggws2005-21-06-12

N-乙酰基转移酶基因多态性与肺癌易感性关系

Relationship between genetic polymorphisms of N-acetyltransferase 2 and susceptibility of lung cancer

摘要

摘要:
目的探讨N-乙酰基转移酶基因2(NAT2)多态性与肺癌易感性关系。
方法采用1:1配对病例-对照研究, 收集江苏省汉族人群原发性肺癌患者215例和相应非肿瘤对照215例。应用PCR-限制性片断长度多态性(RFLP)技术检测病例组与对照组NAT2基因M1、M2和M3等位基因突变频率, 分析NAT2基因多态性与肺癌易感性之间的关系。
结果 M3等位基因频率在肺鳞癌组和对照组的分布差异有统计学意义(χ²=4.30, P < 0.05), 携带M3等位基因者患肺鳞癌危险性增加(OR=1.63, 95%CI=1.03~2.59), 尤其是增加不吸烟者患肺鳞癌的危险性(OR=2.23, 95%CI=1.07~4.65)。未发现NAT2乙酰化基因型与肺癌发生有相关性。
结论 NAT2M3等位基因可能与不吸烟者肺鳞癌易感性有关。

Abstract:
Objective To investigate the relationship between N-acetyltransferase 2(NAT2)genetic polymorphisms and lung cancer susceptibility.
Methods A 1:1 matched case-control study was performed in which 215 hospital controls were matched to the 215 original lung cancer cases.M₁, M₂ and M₃ alleles of NAT2 were detected by PCR-RFLP technique.The association between NAT2 polymorphisms and lung cancer risk was analyzed.
Results The distribution of M₃ allele between lung squamous carcinoma cases and controls was significantly different(χ²=4.30, P < 0.05).M₃ allele was related with increased risk of lung squamous carcinoma(OR=1.63, 95%CI=1.03~2.59), especially in nonsmoking population(OR=2.23, 95%CI=1.07~4.65).No significant association was observed between NAT2 acetylator genotypes and lung cancer risk(P > 0.05).
Conclusion M_{3 >} allele of NAT2 may be associated with susceptbility of lung squamous carcinoma in nonsmo king population.

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