亚甲基四氢叶酸还原酶基因多态与胃癌易感性

毕建萍; 蔡琳; 郑宗立

doi:10.11847/zgggws2005-21-06-14

亚甲基四氢叶酸还原酶基因多态与胃癌易感性

Study on C667T gene polymorphism and susceptibility to gastric cancer

摘要

摘要:
目的探讨福建省人群亚甲基四氢叶酸还原酶(MTHFR)C667T基因多态与贲门癌、非贲门部胃癌易感性关系, 及其与叶酸摄入和饮酒的交互作用。
方法采用共同对照的病例对照研究方法, 聚合酶链反应限制性片段长度多态性(PCRRFLP)方法检测基因型。
结果多因素分析结果显示, MTHFR变异基因型(CT或TT)增加非贲门部胃癌发生的危险。变异基因型与新鲜蔬菜、水果摄入少和常饮酒在贲门癌发生中存在交互作用, 与豆制品和新鲜水果低摄入在非贲门部胃癌发生中存在交互作用。
结论 MTHFR变异基因型与低叶酸和常饮酒协同增加贲门癌发生的危险, 变异基因型是非贲门部胃癌的危险因素, 与低叶酸摄入协同增加非贲门部胃癌的危险。贲门癌与非贲门部胃癌的危险因素不尽相同。

Abstract:
Objective To study the association between genetic polymorphisms of MTHFRC677T and susceptibility to gastric cardia/non cardia cancer, and to investigate the interaction of gene and intake of folates and alcohol drinking in etiology of these cancers in Fujian population.
Methods The case control study with the same control group was conducted.The gene types were investigated by PCR-RFLP.
Results The variated genotype(CT or TT)of MTHFR increased the risk of non-cardia gastric cancer after adjusting for potential confounders.There were interactions between variated genotype and low intake of fresh vegetables, fresh fruits and high drinking of alcohol in cardia cancer group.While the interactions between variated genotype and low intake of pean products, fresh fruits were observed in non-cardia gastric cancer group.
Conclusion The synergies between MTHFR variated genotype and low level of folates intake, high alcohol drinking increase the risk of cardia cancer.The variated genotype is a risk factor of non-cardia gastric cancer.The synergies between genotype and low level of folates intake increase the risk of non-cardia gastric cancer.There maybe different risk factors between cardia and non-cardia gastric cancer.

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