HIV/AIDS患者结核菌素反应及与CD4细胞关系

Relationship between(PPD)skin test result and CD4 cell count in HIV/AIDS positive patients

摘要:
目的分析HIV/AIDS患者结核菌素(PPD)反应及其与CD₄细胞计数间的关系。
方法采取前瞻性对照研究方法, 对202名健康者及40例经免疫蛋白印迹法(WB)确证的HIV/AIDS病人进行PPD试验、CD₄、CD₈淋巴细胞计数。
结果 HIV/AIDS患者中PPD阳性率12.5%, 健康对照PPD阳性率28.2%(P < 0.05)。CD₄细胞计数 < 200/mm³者, PPD均为阴性。CD₄/CD₈比值< 1者达90%。
结论 HIV/AIDS患者机体免疫力降低, PPD反应明显下降。在确诊HIV/AIDS患者并发结核病时应值得注意。

Abstract:
Objective To analyze relation between purified protein derivative PPD skin test result and CD₄ cell count in HIV/AIDS positive patients.
Methods The prospective study was applied.PPD, CD₄ and CD₈ cell counts were examined between 202 health and 40 HIV/AIDS patients confirmed by western blot.
Results 12.5% of HIV/AIDS patients was PPD positive, meanwhile, 28.2% of health was PPD positive, (P < 0.05).All of the CD₄ Cell count below 220/mm³ was PPD negative, the CD₄/CD₈ below 1 accounted for 90%.
Conclusion PPD reaction decreases dramatically with the descending of immunity of HIV/AIDS patients.It is caused attention to diagnose tuberculosis in HIV/AIDS patients.