Objective   To study the effect of Seenriched lactobacillus on spleen NK cell activity in cadmium poisoned rats.

  Methods   Seventy-two healthy Sprague-Dawley female rats were chosen and divided into a control group(group C), a cadmium exposure group of low dose(group L-Cd), a cadmium exposure group of medium dose(group M-Cd)and a cadmium exposure group of high dose(group H-Cd).group C, L Cd, M-Cd, H-Cd were orally dosed daily with 0, 2, 5, 10 mg/(kg·bw) cadmium for 9 weeks, respectively.Forty-eight healthy ICR male mice were chosen and divided randomly into a control group (group C), a cadmium exposure group(group Cd), a cadmium plus medium dose Seenriched lactobacillus group(group Cd-MSe)and a cadmium plus high dose Seenriched lactobacills group(group Cd-HSe).Groups Cd, Cd-MSe and Cd-HSe were in jected in the abdominal cavity with 0.5 mg/(kg·bw)cadmium and group C with saline of the same dosage in group Cd for 12 days.

  Results   During the entire experimental period, spleen NK cell activity of all groups with chronic cadmium exposure decreased, and displayed a relationship which intensified obviously with dosage increases and time elongation of cadmium exposure.The spleen NK cell activity of group Cd with acute cadmium exposure decreased significantly as compared with group C.The activity of group Cd-MSe was close to group C and superior of significantly higher than that of group Cd.The activity of group Cd-HSe was higher than that of group Cd, but lower than that of group C and Cd-MSe.

  Conclusion   A cute and chronic cadmium exposure induced downregulation of NK cell activity.Se enriched lactobacillus could protect effectively the injury in duced by cadmium, and adjusted and ameliorated NK cell activity.