白藜芦醇对去卵巢大鼠生殖系统的影响

肖本熙; 黄忆明

doi:10.11847/zgggws2005-21-08-35

白藜芦醇对去卵巢大鼠生殖系统的影响

Effects of resveratrol on genital system in ovariectomized rats

摘要

摘要:
目的观察白藜芦醇(RES)对去卵巢大鼠生殖系统的影响, 研究其雌激素样作用。
方法 48只SD大鼠随机分为6组, 分别为A组: 假手术、B组: 去卵巢、C组: 去卵巢+0.03mg/(kg·bw)已烯雌酚(DES)、D、E、F组: 去卵巢+RES(分别为5, 15和45mg/(kg·bw)剂量组, 处理90d, 观察大鼠血清雌二醇浓度、动情周期、子宫指数及子宫内膜的变化。
结果 A组血清雌二醇浓度显著高于其余5组(P < 0.05), 子宫指数A组显著高于B、D、E、F组, C组显著高于A组(P < 0.05);阴道涂片显示B组大鼠基本无动情期, C组大鼠动情期明显, D、E、F组大鼠部分出现动情期; D、E、F组子宫内膜部分萎缩变薄, 内薄上皮细胞形态正常, C组大鼠子宫内膜无萎缩, 内膜上皮细胞水肿, 但无明显增生。
结论白藜芦醇在去卵巢大巢体内有较弱的雌激素样作用, 对大鼠子宫内膜无促进增生的副作用。

Abstract:
Objective To investigate the estrogen like effects of resveratrol on ovar iectomized rats.
Methods Forty eight Sprague Dawlery female rats were randomly divided into 6 groups and treated respectively as follows: group A, shamoperated; group B, ovariectomized(OVX); group C, OVX supplemented with 0.03 mg/kgbw·d diethylstilbestrol; and group D, E, F: OVX rats supplemented with 3 dosages of RES(5, 15 and 45 mg/(kg·bw).The duration of exposure was 90 days and the estradiol serum concentration, vaginal smear, uterus index and pathologic examination on uterus of rats were observed.
Results Serumestr adiol concentration of group A was higher than that of the other 5 groups significantly(P < 0.05).Vaginal smear examination showed that resveratrol could induce the estrus occurrencing in the OVX rats.Uterus index of group A was higher than that of the group D, E and F significantly(P < 0.05), but lower than that of group C significantly at the same time.
Conclusion Resveratrol had mild estrogen effect on ovariectomized female rats and without endometrial hy perplasia adverse effect.

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