Objective   To investigate the mechanism that Reduping, a novel endotoxin-antagonist made from traditional Chinese medical herbs, against endotoxemia of heat of heat stroke.

  Methods   To establish the heat stroke model under circum stances of dry bulb temperature(34.5±0.05)and(60±5)% relative humidity.40 mice were randomly divided into five groups includingreduping group, xihuang qijiao group, shengliyanshui group, heat stroke group and normal group.Tumor necrosis factor(TNF-α), superoxide dismutase(SOD)and malondialdehyde(MDA)of blood usingreagent case, the phagocy tosis of macrophage in abdominal cavity using neutral red method and metabolic level of energy using methyl thiazolyl tetra-zolium(MTT)in mice were observed.

  Results   The quantity of TNF-α of Reduping group was lower(P < 0.001)than that of other three groups but similar to normal group; SOD and MDA was higher and lower(P < 0.001)than any other of three groups but similar to normal group; phago cytosis was higher grealty(P < 0.001)than any other of three groups but similar to normal groups and Metabolic level of energy was higher(P < 0.001)than any other four groups.

  Conclusion   One of the most important mechanism that Reduping against endotoxemia of heat stroke is that it can enhance the metabolic level of enery, anti Lipid peroxidation and improve the macrophage phagocytic function.