类毒素-A对小鼠中枢神经系统的毒性

张志红; 屈卫东; 蒋颂辉; 朱惠刚

doi:10.11847/zgggws2006-22-01-22

类毒素-A对小鼠中枢神经系统的毒性

Toxic study of anatoxin-A on central nerves system in mice

摘要

摘要:
目的观察类毒素-A(anatoxin-a, ANTX-A)对小鼠中枢神经系统的亚急性毒性损害.
方法小鼠腹腔染毒不同剂量ANTX-A1个月, 以生理盐水为对照, 用水迷宫试验和被动回避试验测定小鼠的神经行为功能, 并观察中枢神经系统的病理改变.
结果与对照比较, 200μg/(kg·bw)ANTX-A组小鼠在水迷宫试验中逃逸时间和错误次数延长成增多(P < 0.05);200μg/(kg·bw)ANTX-A组小鼠在避暗试验中潜伏期和错误次数延长或增多(P < 0.05);200μg/(kg·bw)ANTX-A组大脑皮质和海马区出现散在的神经元变性利坏死等病理改变.
结论 ANTX-A亚急性暴露可引起小鼠空间学习记忆能力减弱.

Abstract:
Objective To observe the sub-acute toxic effects of ANTX-A on central nerves system(CNS)in mice.
Methods Mice were administered by i.p with different concentrations of ANTX-A for one month.0.9% of sodium chloride solution was used as the control.Neurobehavioral function was measured using Morris water maze test and step-through test, and CNS neuropathological changes were examined.
Results Compared with the control group, escape latency was longer and wrong time was more in 200μg/(kg·bw)ANTX-A-treated group in the Morris water maze test(P < 0.05);Step through latency(STL)was shorter and wrong time was more in 200μg/(kg·bw)ANTX-A-treated group in the step-through test(P < 0.05);Several degeneration and necrosis of neuron were observed in the cortex and hippocampus in 200μg/(kg·bw)ANTX-A-treated group.
Conclusion The special learning and memory function of mice can be retarded by subacute exposure to ANTX-A.

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