硝酸铈对小鼠内脏形态结构影响

干雅平; 章子贵; 申秀英; 许晓路

doi:10.11847/zgggws2006-22-01-40

硝酸铈对小鼠内脏形态结构影响

Effects of crium nitrate on organ pathological changes in mice

摘要

摘要:
目的观察不同浓度的硝酸铈对小鼠各主要内脏脏器系数及形态结构的影响.
方法 84只体重为(20±5)g的小白鼠, 随机分成7组, 分别以0.004, 0.02, 0.1, 0.5, 2.5, 12.5 mg/ml硝酸铈的剂量, 按0.1 ml/10(g·bw)经口灌胃, 每周3次, 连续6周, 对照组灌以等剂量的生理盐水.染毒结束后处死动物, 迅速取肝脏、肺、肾脏、脾脏, 用生理盐水清洗后准确称重, 并进行各脏器组织切片的光镜检查.
结果低浓度的铈使肝体比显著下降, 而各浓度的铈都能使肾体比极显著升高.当Ce(NO₃)₃剂量≥0.5 mg/ml时, 肝脏、肺和肾脏有明显的病理性变化.
结论铈具有较强的毒害作用, 其作用的主要靶器官为肝脏、肺和肾脏.

Abstract:
Objective To obsreve the effects of cerium nitrate on the main organ coefficient and pathological changes.
Methods Cerium Nitrate was administered to 84 mice by gavage at 0.004, 0.02, 0.1, 0.5, 2.5, 12.5 mg/ml for a period of 6 weeks.The weight and or gan coefficient were accounted and pathological changes were observed with potical microscope.
Results Relat ively weight of liver in low concentration g roup were lower than those of control.Relat ively weight of kidney of mice were all remarkbly higher than that of control.Liver, lung and kidney all had significant pathologic changes after with Ce(NO₃)₃yingwenzy.5 mg/ml.
Conclusion Cer ium is poisonous, and mainly has effects on the liver, lung and kidney.

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