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李阳桦, 李辉, 龚晓红, 王富珍, 刘立荣, 王化勇, 孙晓云, 苏燕萍, 韩庆英, 张海燕. 北京市乙肝疫苗初免后3~12岁儿童加强免疫观察[J]. 中国公共卫生, 2006, 22(3): 313-314. DOI: 10.11847/zgggws2006-22-03-34
引用本文: 李阳桦, 李辉, 龚晓红, 王富珍, 刘立荣, 王化勇, 孙晓云, 苏燕萍, 韩庆英, 张海燕. 北京市乙肝疫苗初免后3~12岁儿童加强免疫观察[J]. 中国公共卫生, 2006, 22(3): 313-314. DOI: 10.11847/zgggws2006-22-03-34
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LI Yanghua, LI Hui, GONG Xiaohong, . Study on reminiscent responsion of Hepatitis B vaccine booster immunization in 3~12 years-old children of Beijing[J]. Chinese Journal of Public Health, 2006, 22(3): 313-314. DOI: 10.11847/zgggws2006-22-03-34
Citation: LI Yanghua, LI Hui, GONG Xiaohong, . Study on reminiscent responsion of Hepatitis B vaccine booster immunization in 3~12 years-old children of Beijing[J]. Chinese Journal of Public Health, 2006, 22(3): 313-314. DOI: 10.11847/zgggws2006-22-03-34
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北京市乙肝疫苗初免后3~12岁儿童加强免疫观察

Study on reminiscent responsion of Hepatitis B vaccine booster immunization in 3~12 years-old children of Beijing

    摘要
  • 摘要:
      目的   评价北京市儿童进行乙肝疫苗加强免疫接种后抗-HBs的应答反应水平。
      方法   采取多阶段整群系统抽样选择已进行乙肝疫苗初免的3~12岁儿童, 采用固相放射免疫(SPRIA)方法, 检测血清HBsAg、抗-HBs和抗-HBc水平, 其中抗-HBs < 10 Iu/L者进行不同剂量的己肝疫苗加强免疫, 观察加强免疫后的抗-HBs。
      结果   2 491名3~12岁儿童的抗-HBs阴性率为48.25%(CI%=35.15~64.26);对其中726名儿童进行己肝疫苗加强免疫后, 接种2.5和5μg疫苗的儿童抗-HBs的阳转率分别为90.6%和90.9%, GMT分别为85.69和87.59 Iu/L, (χ 2=0.02, P=0.89; t=0.36, P=0.72)。加强免疫后4~5周, 平均抗-HBs的阳转率为92.8%, GMT为84.55 Iu/L; 免后6~22周采血, 平均抗-HBs的阳转率为86.66%, GMT为91.39 Iu/L, 2个时间段的抗-HBs的阳转率差异有统计学意义(χ 2=7.47, P=0.006)。
      结论   3~12岁完成乙肝疫苗基础免疫的儿童, 在抗体消失后给予一定剂量的乙肝疫苗进行加强免疫, 其抗-HBs反应良好, 表明机体存在对乙肝病毒有回忆反应, 可能是维持乙肝疫苗长期保护效果的原因之一。

     

    Abstract:
      Objective   To evaluate the character of the reminiscent responsion of the Hepatitis B vaccmebooster immunization on the children who were anti-HBs negative in Beijing.
      Methods   The multiple stratified cluster sampling was used in this epidemiological survey.The sampling children's blood serum HBsAg, antiHBs and antiHBc were checked and measured by the Solid Phase Radioimmunoassay(SPRIA).The children whose antiHBs serological titer(GMT)was lower than 10 Iu/L had the Hepatitis B vaccine booster immunization in two different dosages.
      Results   2 419 3~12 years-old children who were immunized by the Hepatitis B vaccine in the infant period were surveyed and the total anti-HBs negative rate was 48.25% (CI%, 35.15~64.26).725 children had the Hepatitis B vaccine booster immunization and the antiHBs positive rate was observed.The antiHBs positive rate of the children who were immunized in 2.5 μg and 5.0 μg Hepatitis B vaccine was 90.6% and 90.9% respectively.The GMT was 85.69 and 87.59 Iu/L respectively.The antiHBs positive rate was also analyzed according to the different time of the blood sampling.And there were both no statistical significances between the two dosages(χ 2=0.02, P=0.89; t=0.36, P=0.72).The average antiHBs positive rate was 92.80% and the GMT was 84.55 Iu/L after 4~5 weeks.The average antiHBs positive rate was 86166% and the GMT was 91.39 Iu/L after 6~22 weeks.There were statistical significance for the average antiHBs positive rate(χ 2=7.47, P=0.006)and no statistical significance for the antiHBs GMT between the different blood samplmg time(t=1.09, P=0.28).
      Conclusion   For the 3~12 year-sold children who had finished the basic immunization of Hepatitis B vaccine in the infant period, a little dose of Hepatitis B vaccine could make responsion strongly in their bodies after the antibody died away.It showed that there was remimscent responsion for the Hepatitis B virus in their bodies.This reminiscent responsion could be the main cause that made people have the long-term protection of Hepatitis B vaccine.

     

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