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汤晴, 朱天义. 磷脂酶A2调节对大鼠肝癌前病变作用[J]. 中国公共卫生, 2006, 22(3): 317-318. DOI: 10.11847/zgggws2006-22-03-36
引用本文: 汤晴, 朱天义. 磷脂酶A2调节对大鼠肝癌前病变作用[J]. 中国公共卫生, 2006, 22(3): 317-318. DOI: 10.11847/zgggws2006-22-03-36
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TANG Qing, ZHU Tianyi. Effects of phospholipase A2 on preneoplastic lesions in rat liver[J]. Chinese Journal of Public Health, 2006, 22(3): 317-318. DOI: 10.11847/zgggws2006-22-03-36
Citation: TANG Qing, ZHU Tianyi. Effects of phospholipase A2 on preneoplastic lesions in rat liver[J]. Chinese Journal of Public Health, 2006, 22(3): 317-318. DOI: 10.11847/zgggws2006-22-03-36
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磷脂酶A2调节对大鼠肝癌前病变作用

Effects of phospholipase A2 on preneoplastic lesions in rat liver

    摘要
  • 摘要:
      目的   观察磷脂酶A 2调节的鼠肝癌发生过程, 即癌前病灶转化为增生结节过程中的作用, 探讨磷脂酶A 2对肝癌发生影响。
      方法   利用大白鼠复制肝癌前病变发生的动物模型。然后将带有癌前病灶的大鼠分组。实验组分别给0.75%, 1.5%-ρbromophenacylbromie(BPB), 加有或不加0.05%苯巴比妥(PB)的饲料, 对照组只给单纯0.05%PB饲料或基础饲料喂养9周。处死取肝后, 进行r-谷胺酰转换酶(GGT)组化染色和HE染色。
      结果   0.75%, 1.5%BPB、加有或不加PB的实验组中, 单位面积的GGT染色阳性的持续性结节数和HE染色的肝细胞增生性结节数与相应对照组相比显著减少(P < 0.05)。
      结论   2种浓度的BPB在有或没有PB-癌促进剂作用下, 均在肝癌前病灶转化为增生结节的过程有抑制作用, 提示磷脂酶A 2参与肝癌的发生过程。

     

    Abstract:
      Objective   To investigate effects of phospholipase A 2 on hepatocarcinogenesis, ρ-bromophenacylbromide(BPB), one of inhibitors of phospholipase A 2, was observed on procedure from preneoplastic foci into nodules in rat liver.
      Methods   Inducing preneoplastic liver foci, then rats bearing foci were given diets containing 0.75%, 1.5% BPB with or without 0105% Phenobarbital (PB), 0.05% PB alone and basal diet for 9 weeks.Liver slices made GGT staining and HE staining.
      Results   Both doses BPB either with or without PB, significantly decreased the numbers of persistent nodules and hyperplastic nodules.
      Conclusion   Both doses BPB inhibited the evolution of preneoplastic foci into nodules in rat liver with or without PB exposure, suggesting that phospholipase A 2 involves in hepatocarcinogenesis in rats.

     

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