Objective   To study the effect of fluorine, selenium and cadmium on lipid peroxide(LPO)and microelements in the tisue of rats.testicle.

  Methods   T he contents of LPO, glutathione peroxidase(GSH-Px)and microelements such as cadmium, selenum, zinc and iron in the tissue of SD rats.testicle after killing SD rats that had druken water containing fluorine, selenium, cadmium or any two of the three elements or all of them.

  Results   In fluorine group and cadmium group, the contents of LPO noticeably increased and the conternts of GSH-Px remarkably reduced in the testicle of rats, and the selenium group wasn't notably change.The contents of LPO remarkably reduced and GSH-Px noticeably increased in which contaminted with the combination of three or any two of the three elements when comared with those in the rats contaminated with any one element of them.Compared with those of rats without being contaminated, the contents of selenuium had on obvious change, the contents of cadmium, seleium, zinc and iron in he fluorine group weren't noticeably change, the contents of cadmium and iron obviously increased in cadmium geroup, the contents of zinc and iron noticeably increased in selenium group or in group of selenium and fluorine, and in group of cadmium and selenium, or fluorine and cadmium, or fluorine, selenium and cadmium, the contents of cadmim and iron noticeably incresed.

  Conclusion   Fluorine, cadmium can accelerate the activity of GSH-Px in the testicle of rat, which can diminsh the antioxidation ability of the testicle.But selenium had no obvious effect on them, when two of the fluorine, selenium and cadmium coexist, they can reduce the content of lipid perox ide and the effect is even stronger when three of them coexist.Selenium can reduce the accumulation of cadmium, and raise the level of selenium and zinc.Fluorine of selenium or cadmium can raise the level of iron in the testicle, and all of them combined to produce a more powerful effect.