不同人群感染丙型及庚型肝炎病毒危险性分析

洪楷; 丁映淑; 陈林兴; 邱杰文

doi:10.11847/zgggws2006-22-03-53

不同人群感染丙型及庚型肝炎病毒危险性分析

Risk of hepatitis C and G infection in different populations

摘要

摘要:
目的研究不同人群感染丙型肝炎病毒(HCV)及庚型肝炎病毒(HGV)的危险性并探讨其传播途径。
方法采集不同人群的血清, 运用酶联免疫吸附试验(ELISA)及荧光定量聚合酶链式反应(FQ-PCR)检测抗-HCV、抗-HGV及HCV-RNA、HGV-RNA。
结果一般人群、医护人员、普通孕妇、乙型肝炎病人、血液透析(HD)病人抗-HCV的阳性率分别为0.89%(58/6468), 2.93%(5/171), 0.93%(17/1836), 11.5%(47/410)和51.4%(54/105), 抗-HGV的阳性率为0.6%(3/500), 0(0/171), 2.5%(6/240), 9.3%(13/140)和14.3%(5/105);母婴传播率HCV为16.7%;HGV为25%。血液透析(HD)病人有无输血史HCV感染率差异有统计学意义(χ²=7.72, P < 0.01)。
结论有血液暴露史者是HCV及HGV感染的高危人群; 血液及母婴传播是重要的传播途径。

Abstract:
Objective To investigate the HCV and HGV infection rate from the different populations and its route of transmission.
Methods Serum samples from the different populations were tested for anti-HCV and anti-HGV by ELISA.HCV-RNA and HGV-RNA was detected by FQ-PCR.
Results Anti-HCV positive rates for general crowd, clinical medical workers, pregnant women, hepatitis B patients and blood donors were 0.89%, 2.93%, 0.93%, 11.5% and 51.4%.Anti-HGV positive rates were 0.6%, 0, 2.5%, 9.3% and 14.3%.the rates of mother-to-infant transmission of HCV and HGV were 16.7% and 25%.The Anti-HCV positive rates for blood transfusion and no blood transfusion had extremely significant differences(χ²=7.72, P < 0.01).
Conclusion The high risk people of hepatitis C and G infection was blood transfusion.Mother-to-infant transmission and blood transfusion were major way of HCV and HGV infection.

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