妊娠糖尿病危险因素病例对照研究

强兆艳; 王建华; 齐秀英

doi:10.11847/zgggws2006-22-07-16

妊娠糖尿病危险因素病例对照研究

A case-control study on risk factors of gestational diabetes mellitus

摘要

摘要:
目的探讨妊娠糖尿病(GDM)的危险因素。
方法采用1:4配比病例对照研究方法, 对行孕期健康检查的孕妇以问卷调查的方式收集现病史、孕产史、家族史、个人习惯、社会心理因素、父母情况等, 并于首诊及孕24~48周进行体格检查和实验室检查, 包括50 g葡萄糖激发试验(GCT)和75 g口服葡萄糖耐量试验(OGTT)实验等。
结果糖尿病家族史、父母患恶性肿瘤、孕前体质指数(BMI)、首诊腰髋比(WHR)、首诊股围与GDM的发生之间有统计学关联。OR值及其95%CI分别为6.930(1.840~26.105), 13.804(1.552~122.75), 4.947(1.274~19.203), 5.609(1.492~17.227)和6.269(1.867~21.045)。
结论有糖尿病家族史、父母患恶性肿瘤、孕前BMI > 26、WHR≥0.9、首诊股围 > 60 cm是GDM发生的危险因素。

Abstract:
Objective To explore the risk factors of gestatinal diabetes mellitus(GDM).
Methods A hospital-based 1:4 matched case-control study was conducted.Each case was matched with four controls on age.21 GDM cases and 84 pregnant women without GDM were recruited.Information was collected through face-to-face interview, which included deographic data, disease history, disease family history, behavior pattern, social psychologic character, clinical data and laboratory data.
Results
Results from univariate conditional logistic regression analysis showed that GDM was associated with diabetic family history, family history of cancer, BMI, WHR and thigh circumference.The correspondingOR with 95% CI were 6.930 (1.840~26.105), 13.804(1.552~122.75), 4.947(1.274~19.203), 5.069(1.492~17.227)and 6.269(1.867~21.045)respectively.
Conclusion Diabetic family historty, family history of cancer, BMI > 26, WHR≥0.9 and thigh circumference > 60 cm were associated with higher risk for the development of GDM.

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