C反应蛋白与肥胖大鼠胰岛素抵抗相关性

吴辉; 姚兴家; 吴畏; 郑琳琳; 翟玲玲; 熊迎九

doi:10.11847/zgggws2006-22-07-23

C反应蛋白与肥胖大鼠胰岛素抵抗相关性

摘要

摘要:
目的探讨饮食诱导肥胖大鼠血清C-反应蛋白(CRP)与胰岛素抵抗(IR)的关系。
方法 30只雄性Wistar大鼠随机分成对照组和高脂组, 分别喂基础饲料和高脂饲料12周, 测定12周末空腹血糖(FPG)、空腹胰岛素(FINS)、血清CRP、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平, 以胰岛素敏感指数(ISI)判定机体胰岛素抵抗(IR)状态。
结果 12周末, 高脂组大鼠血清CRP、TNF-α、IL-6水平分别为(2.933±1.039)mg/L, (2.029±0.152)μg/L, (130.32±23.28)ng/L, 均高于对照组(P < 0.05), 而且TNF-α、IL-6分别与CRP呈正相关(P < 0.05), CRP与ISI呈负相关(P < 0.05)。
结论 CRP可能涉及肥胖及肥胖相关的IR。

Abstract:
Objective To study the level of serum c-reactive protein(CRP) and the association w ith insulin resistance (IR) in obese rats induced by diet.
Methods Thirty male Wistar ra ts w ere randomly divided into control group and hig h fat group.They were respectively fed on standard diet and hig h fa t diet for 12 w eeks.Then the levels of serum fasting plasma glucose(FPG) and fasting insulin(FINS), CRP, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) were measured.IR w as assessed by insulin sensitivity index(ISI).
Results The levels of serum CRP, TNF-α, IL-6 in high fat group were(2.933 + 1.039) mg/ L, (2.029 +0.152) μg/ L, (130.32 ±23.28) ng/ L respectively after 12 w eeks.They were higher than those of control group(P < 0.05).Positive correlation was found between TNF-αand CRP(P < 0.05), IL-6 and CRP(P < 0.05), negative correlation w as found between CRP and ISI(P < 0.05).
Conclusion CRP might be involved in obesity and insulin resistance related to obesity.

HTML全文

参考文献(6)

施引文献

资源附件(0)