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刘丽英, 李连永, 王莉莉, 张炫, 吉士俊, 张力军, 金春莲, 孙开来. 东北地区先天性马蹄内翻足病例-对照研究[J]. 中国公共卫生, 2006, 22(7): 831-832. DOI: 10.11847/zgggws2006-22-07-39
引用本文: 刘丽英, 李连永, 王莉莉, 张炫, 吉士俊, 张力军, 金春莲, 孙开来. 东北地区先天性马蹄内翻足病例-对照研究[J]. 中国公共卫生, 2006, 22(7): 831-832. DOI: 10.11847/zgggws2006-22-07-39
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LIU Liying, LI Lianyong, WANG Lili, . A case-control study on Idiopathic Talipes Equinovarus in northeast region of China[J]. Chinese Journal of Public Health, 2006, 22(7): 831-832. DOI: 10.11847/zgggws2006-22-07-39
Citation: LIU Liying, LI Lianyong, WANG Lili, . A case-control study on Idiopathic Talipes Equinovarus in northeast region of China[J]. Chinese Journal of Public Health, 2006, 22(7): 831-832. DOI: 10.11847/zgggws2006-22-07-39
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东北地区先天性马蹄内翻足病例-对照研究

A case-control study on Idiopathic Talipes Equinovarus in northeast region of China

    摘要
  • 摘要:
      目的   探讨中国东北地区(辽宁、吉林, 黑龙江省)先天性马蹄内翻足(Idiopathic Talipes Equinovarus, ITEV)发生的可能危险因素。
      方法   以随访和问卷调查方式获得121个ITEV患者家系资料信息, 同时选择220个正常者与其相匹配, 进行病例-对照研究。
      结果   排除9例因合并其他畸形的ITEV患者后, 剩余112例, 男性与女性患者比为2.6:1, 双侧马蹄足约占50%;在单侧发病的病例中, 右侧多于左侧。夏冬季发病率明显高于春秋季节。在众多环境因素中, 母亲孕前及孕期服药在对照组与病例组之间差异有统计学意义(χ2=8.64及13.49, P < 0.01);孕期胎儿发育受限占病例组总例数的65.2%, 与对照组相比差异有统计学意义(χ2=49.29, P < 0.01), 是ITEV的高危因素; 母亲孕期吸烟、饮酒及患病史在病例组及对照组间差异无统计学意义(P > 0.05)。
      结论   母亲孕前及孕期用药、胎儿发育受限可能是ITEV的危险因素。

     

    Abstract:
      Objective   To investigate the properetiology of Idiopathic Talipes Equinovarus(ITEV)in Liaoning, Jilin and Heilongiang province of China.
      Methods   121 proposita data information were obtained by follow-up and questionnaire survey.220 normal person infor mation matched with control group to complete case-control study for some risk factors of ITEV.
      Results   9 persons were excluded since they had some other defor mities.After this process.112 proposita were involved.The ratio of ITEV between male and female was 2.6:1, and bilateral deformity was seen in 50% or more of ITEV cases.And in unilater al cases, the right side was more often involved than that of left side.There were more ITEV births in summer/winter than that of spring/autumn.Among all environmental factors, taking medicine before or during pregnancy was significant difference between case and control group(χ2=8.64 and 13.49;P < 0.01).And 65.2% mother had abnormal uterus factors in case group, which had significant difference compared with control group(χ2=49.29, P < 0.01).There was no difference in maternal smo king, drinking and having disease during pregnancy between case and control group(P > 0.05).
      Conclusion   Taking medicine before or during pregnancy and abnormal uterus factors may play important roles in etiology of ITEV.

     

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