父亲与新生儿乙型肝炎病毒传播感染方式调查

周小辉; 王莹; 于桂琴; 曾荔苹; 张凌凌; 黄恬

doi:10.11847/zgggws2006-22-09-01

父亲与新生儿乙型肝炎病毒传播感染方式调查

Investigation on paternal-fetal transmission of hepatitis B virus in neonates

摘要

摘要:
目的了解乙型肝炎病毒(HBV)感染父亲的新生儿群体中, HBV的感染和流行情况。
方法筛选230名慢性HBV感染的父亲而母亲则无乙型肝炎病毒标志物(HBVM)的新生儿为研究对象, 进行HBVM测定, 另一组父母均无HBV感染标志的新生儿为对照组。
结果 44名新生儿血清HBV DNA阳性(阳性率为19.13%), 测其含量为(6.851±2.317), 其中40名父亲的血清HBV DNA含量为(7.345±1.572), 两者之间经统计学分析无数量上的相关关系。
结论 HBV感染男性其子代中有较高的HBV感染率, 提示HBV可以通过父婴垂直传播方式传染给新生儿。父亲与新生儿血清HBV DNA复制水平无相关性。

Abstract:
Objective To evaluate the infection and prevalence of hepatitis B virus(HBV)in the neonates whose fathers were chronic HBV carriers.
Methods 230 neonates whose fathers were chronic HBV carriers and mothers were negative for any HBV marker were chosen to detect HBV marker(HBVM), 40 neonates whose parents were both negative for any HBV marker were controlled.
Results The serum HBV DNA of 44 neonates in studied group(19.13%)were detected positive from their umbilical blood whereas those in controlled group had negative for HBVM.The serum HBV DNA were 6.851±2.317(logarithm)in the neonates and 7.345±1.572(logarithm)in their fathers.There was not correlation between the neonates and their fathers in serum HBV DNA levels.
Conclusion The HBV infectious rates among the neonates whose fathers are HBV carriers are relatively higher.The hepatitis B virus can be transmitted from the fathers to their neonates vertically.The level of serum HBV replication of fathers with chronic HBV carrier is no correlation with their neonates.

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