维生素D受体基因多态性与食管癌易感性关系

Association of vitamin D receptor polymorphism with susceptibility to esohageal cancer

摘要:
目的探讨维生素D受体基因的多态性与食管癌易感性的关系。
方法收集92例食管癌患者及115名对照, 用聚合酶链反应-限制性片段长度多态性方法(PCR-RFLR), 在维生素D受体基因的3'端分析限制性酶切位点TaqⅠ的多态分布。
结果 TaqⅠ位点等位基因在2组间分布差异有统计学意义。与TT基因型者相比, Ttt、t基因型者患食管癌的危险性明显下降。
结论维生素D受体基因的多态性与食管癌有关, Ttt、t基因型降低食管癌的易感性。

Abstract:
Objective To explore the association between vitamin D receptor(VDR)polymorphism and the susceptibility to esophageal cancer.
Methods Polymerase chain reaction-restriction fragent length polymorphism(PCR2RFLP)method was used.A restriction fragment length polymorphism in the 3'region of VDR gene, TaqⅠ, was tested in 92 patients with esophageal cancer and 115 healthy controls.
Results Allele frequencies of TaqⅠpolymorphism had significant differences between the two groups.Compared with people with TT genotype, those with Tt and tt genotypes had less risk to esophageal cancer.
Conclusion There is an association between VDR plymorphism and the susceptibility to esophageal cancer, and Tt and tt genotypes decline the susceptibility to esophageal cancer.