维生素E对染铅兔周围神经功能的保护作用

黄陈平; 林林; 叶晓蕾; 黄晓颖

doi:10.11847/zgggws2006-22-09-26

维生素E对染铅兔周围神经功能的保护作用

Protective effects of vitamin E on peripheral nerve function of rabbits exposed to lead

摘要

摘要:
目的在研究铅染毒机体脂质过氧化水平与周围神经功能关系的基础上, 观察维生素E(VE)对染铅兔周围神经功能的保护作用。
方法 24只家兔随机分为3组, 即单纯染铅组(Ⅰ)、铅+VE组(Ⅱ)和对照组。Ⅰ、Ⅱ组饮用0.1%醋酸铅水, Ⅱ组还予以VE皮下注射2 mg/(kgºbw), 每周2次, 对照组不予以铅染毒及VE保护, 持续8周。测定股神经传导速度(NCV)及血浆、脑匀浆丙二醛(MDA)和总超氧化物歧化酶(T-SOD)水平, 分析MDA、T-SOD与NCV之间的关系。
结果 Ⅰ组NCV显著低于对照组(P < 0.01)和Ⅱ组(P < 0.01), NCV与血、脑MDA之间呈负相关关系(r=-0.408, -0.464, P < 0.05), 但各组间MDA、T-SOD差异均无统计学意义。
结论铅染毒能引起NCV减慢, NCV减慢与脂质过氧化水平有关, 脂质过氧化损伤可能是铅中毒性周围神经病的机制之一。VE能减轻铅的神经毒性, 具有保护和改善周围神经功能的作用。

Abstract:
Objective To study the effects of Vitamin E(VE)on the lipid peroxidation and Nerve Conduction Velocity (NCV)of rabbits exposed to lead(Pb).
Methods 24 rabbits were randomly divided into 3 groups(Pb group(Ⅰ), Pb+VE group(Ⅱ)and control group).Ⅰ and Ⅱ group rabbits drank water of 0.1% lead acetate freely for 8 weeks, Ⅱgroup rabbits were still given 2 mg/kg VE ih, 2 times a week.Control group rabbits drank no Pb water and had no VE treatment.At the end of the experiment, the thigh NCV, Malondialdehyde(MDA)and Tota-l Superox ide Dismutase(T-SOD)in plasma and brain were mearsued.
Results The NCV of Ⅰ group were sig nificantly decr eased(P < 0.01)than those of the control andⅡ groups.There were significantly negative correlation between NCV and plasma or brain SOD(r values: -0.408, -0.464, P < 0.05), but the differences of SODor MDA among the groups were still insignificant in statistically.
Conclusion Lead poisoning can decrease NCV, which has a relationship with the level of lipid perox idation.The effects of lipid perox idation may be the mechanism of peripheral neur opathy induced by lead poisoning.VE can alleviate the har mful effects of lead by its anti-oxidation and impr oving the function of peripher al nerves.

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