八氯二丙醚暴露工人微核及DNA损伤程度

Micronuclei and DNA damage in peripheral lymphocyte of workers occupationally exposed to octachlorodipropyl ether

摘要:
目的了解八氯二丙醚暴露可能对工人造成的健康危害。
方法对八氯二丙醚(S2)生产工人进行流行病学调查, 并采集外周血进行微核(MN)和单细胞凝胶电泳试验(SCGE), 了解S2可能对工人健康的损伤。
结果八氯二丙醚接触者外周血微核发生率较对照组无明显增加(P > 0.05), DNA表现出不同程度的损伤(P < 0.01)。
结论目前S2生产车间有害气体的暴露水平对工人外周血DNA有一定的损伤作用。

Abstract:
Objective To understand the effects of octachlorodipropyl ether on the health of workers.
Methods To make an epidemiological survey of the wor kers occupationally exposed to octachlorodipropyl ether(S2)by micronucleus test and single cell gel electrophoresis assay(SCG E).
Results There was no significant increase in frequency of micronuclei of those-exposed to octachlorodipropyl ether(S2)as compared with the control group.DNA damage was more severe in the group exposed to octachlorodipropyl ether(S2).
Conclusion Occupational exposure to S2 producing process may cause DNAdamages in peripheral Lymphocyte of workers.