混配农药对家兔诱发电位及脑组织ATP酶的影响

林立; 张璟; 曾晓立; 张强

doi:10.11847/zgggws2006-22-09-54

混配农药对家兔诱发电位及脑组织ATP酶的影响

Effects of mixed pesticides on somatosensory evoked potential and activities of ATPase of brains in rabbits

摘要

摘要:
目的研究混配农药对家兔中枢神经系统功能的影响及其机制。
方法将家兔随机分为混配农药染毒A组(丙溴磷与氰戊菊酯混配染毒组)、混配农药染毒B组(丙溴磷与灭多威混配染毒组)和1个对照组, 每组6只。3个染毒组分别给予3种染毒剂量进行染毒, 于染毒前后进行家兔体感染诱发电位(SEP)及染毒后大脑组织三磷酸腺苷(ATP)酶活力的测定。
结果与对照组比较, 2个混配农药染毒组的高剂量组染毒后SEP的N1、P1、N2波潜伏时均显著延长(P < 0.01), 2个混配农药染毒组的高中剂量组染毒后的Na⁺-K⁺-ATP酶、Ca²⁺-Mg²⁺-ATP酶的活力明显下降(P < 0.05, P < 0.01)。
结论一定剂量的混配农药可导致家兔中枢神经系统功能的的改变, 这种改变可能与大脑组织中Na⁺-K⁺-ATP酶、Ca²⁺-Mg²⁺-ATP酶活力的下降有关。

Abstract:
Objective To explore the effects of mixed pesticides on the Somatosensory evoked potential(SEP)and the activities of ATPase of brains in rabbits.
Methods Rabbits were divided into 2 mixed pesticide ex posure groups and 1 control group.A group were poisoned by profenofos and fenvalerate, and B group were poisoned by profenofos and methomyl.The SEP were measured in each group before and after poisoning by mixed pesticide, and the activites of Na⁺-K⁺-AT Pase and Ca²⁺-Mg²⁺-ATPase of the brain was measured in each group after poisoning by mixed pesticide.
Results Compared with the control group, the potential periods of N1, P2, N2 in high-dose exposure group in Agroup and Bgroup delayed significantly after poisoning by mixed pesticide(P < 0.01).Compared with the control group, the activities of Na⁺-K⁺-ATPase and Ca²⁺-Mg²⁺-ATPase decr eased significantly in high-dose exposure groups and middle-dose groups in A group and B group after poisonging by mixed pesticide(P < 0.05, P < 0.01).
Conclusion The mixed pesticides can harm the functions of central nervous system, which must be related to the decrease of the activities of Na⁺ K⁺-ATPase and Ca²⁺-Mg²⁺-ATPase in brain.

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