E-钙粘附素基因多态性与胃癌遗传易感性

路滟; 徐耀初; 沈靖; 喻荣彬; 钮菊英; 郭剑涛; 胡旭; 沈洪兵

doi:10.11847/zgggws2006-22-12-06

E-钙粘附素基因多态性与胃癌遗传易感性

Relationship between polymorphism of E-cadherin gene and genetic susceptibility of non-cardia gastric cancer

摘要

摘要:
目的探讨E-钙粘附素基因(CDH1)启动子区-160 CA多态性与胃癌遗传易感性的关系。
方法应用以人群为基础的病例对照研究, 采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测胃癌病例组与健康对照组的-160CA多态改变的频率。
结果 CDH1-160CA多态改变在胃癌病例组中的频率分别是CC型为57.8%、CA型为36.4%、AA型为5.8%, 对照组各型频率分别是CC型为58.2%、CA型为34.9%、AA型为6.9%。调整年龄、性别、地区、吸烟、饮酒、饮茶、H.pylori感染以及胃癌家族史等因素后, CDH1各基因型在2组间差异均无统计学意义(χ²=0.29, P=0.87);将CA基因型与AA基因型合并后进行病例组与对照组之间的比较, 差异无统计学意义(χ²=0.01, P=0.92)。
结论 E-钙粘附素基因(CDH1)启动子区-160CA多态性与胃癌遗传易感性不相关。

Abstract:
Objective To test the hypothesis that a C to A variant in promoter of E-cadherin gene, which is associated with risk of developing non-cardia gastric cancer.
Methods Population based case-control study was used and the polymerase chain reaction-restriction fragment length poly morphisms(PCR-RFLP)was used to genotype this variant in 207 non-cardia gastric cancer patients and 270 age-sex frepuency-matched cance-rfree controls.
Results The distributions of CDH1 genotypes were not significantly different between cases and controls(χ²=01 29, P=0.87).Compared with the CC genotype, the variant CA and AA genotypes were not associated with an increased risk of gastric canceradjusted odds ratio(ORa)were 1.15, 0.90 respectively; 95% confidence interval(CI)were 0.87-1.72, 0.42-2.01 respectively.
Conclusion The C160a promoter polymorphism of E-cadherin gene may not play a major role in the etiology of non-cardia gastric cancer.

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