亚甲基四氢叶酸还原酶基因多态性与宫颈癌易感性

马晓晨; 王金桃; 周溱; 丁玲; 程玉英; 王志敏; 弟娟娟

doi:10.11847/zgggws2006-22-12-10

亚甲基四氢叶酸还原酶基因多态性与宫颈癌易感性

Relationship between Methylenetetrahydrofolate reductase polymorphism and cervical cancer susceptibility

摘要

摘要:
目的探讨山西省人群亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与宫颈癌易感性的关系。
方法采用以医院为基础的病例对照研究, 调查111例病理确诊的宫颈鳞状细胞癌和111例子宫肌瘤对照可能危险因素的暴露情况, 聚合酶链限制性长度多态性的(PCR-RFLP)方法检测MTHFR基因多态性; 多因素Logistic回归模型进行危险因素的分析。
结果多因素分析结果显示, 677TT基因携带者患宫颈癌的危险是677CC型个体的3.29倍(OR=3.29, 95%CI=1.33~8.16), 是C等位基因(CC+CT)携带者的2.74倍(OR=2.74, 95%CI=1.31~5.74)。
结论 MTHFR基因C677T多态性可能是宫颈癌发生的易感因素, 携带677TT基因型的个体患宫颈癌的危险明显增加。

Abstract:
Objective To explore the Municipal relationship between the MTHFR polymorphism and cervical cancer susceptibility.
Methods The hospital-based case-control study was carried out, the risk factors of 111 cases with cervical cancer by pathological diagnosis and 111 patients with hysterteromyoma were investigated, MTHFR C677 Tpolymorphism was analyzed by PCR-RL FP.Logistic regress was used to perform the risk factors analysis.
Results The variated genotype of M THFR increase the risk of cervical cancer, adjusted odds ratio computed for T/T versus C/C was 2.91(95%CI=1.09~7.75), adjusted odds ratio computed for TT/non-T/T was 2.58(95%CI=1.22~5.45).
Conclusion The mutant type homozygote of MTHFR C677T was a risk factor of cervical cancer.The risk of cervical cancer increased in women who had MTFHR677TT gene type.

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