不同性别高敏C-反应蛋白与代谢综合征关系

康国栋; 郭志荣; 武鸣; 周惠; 陈冯梅; 刘仕俊; 胡晓抒

doi:10.11847/zgggws2006-22-12-23

不同性别高敏C-反应蛋白与代谢综合征关系

Association of high sensitivity C-reactive protein and metabolic syndrome in men and women

摘要

摘要:
目的探讨江苏省男、女性中高敏C-反应蛋白(hs-CRP)浓度与代谢综合征(MS)的关系及其影响因素。
方法采用横断面研究的方法, 在江苏省多代谢异常和代谢综合征综合防治研究基线调查资料中选择1 039名男性和1 291名女性作为研究对象, 测量研究对象的身高、体重、腰围、血压, 计算体质指数(BMI); 检测血清中hs-CRP、血脂、血糖、高密度脂蛋白、低密度脂蛋白。采用Logistic回归分析影响男、女性hs-CRP浓度与MS的关系。
结果女性随着hs-CRP浓度的增加患MS的危险增加(P < 0.01)。而男性hs-CRP浓度与MS的关系则不明显(P=0.08)。女性中这种联系在调整年龄、吸烟、饮酒、高血压家族、糖尿病家族史后仍存在, 但在进一步调整体质指数后这种关系消失。
结论 BMI是影响hs-CRP浓度的主要因素。女性随着hs-CRP浓度的升高, 患MS的危险也相应增加, 而男性中hs-CRP浓度与MS的联系则不显著。

Abstract:
Objective To determine the association of high-sensitivity C-Reactive Protein(hs-CRP).And metabolic syndrome(MS)and its influencing factors in men and women of Chinese.
Methods In this cross-sectional study, total 2 330 (1 039 men and 1 291 women)part icipants were included.MS criteria was defined by IDF.All Participants body height, weight, waist circumference, blood pressure, body mass index(BMI), hs-CRP level, blood fat, fasting glucose, high density lipoprotein, low density lipoprotein were measured.Logistic regression was used analyze the association of hs-CRP level and MS in men and women.
Results The risk of developing MS incr eased with the level hs-CRP in women(P < 0.01), but there's no association in men(P=0.08).This association still existed after adjusted age, smoking, drinking, family history of hypertension and family history of diabetes in women.However, the association was no longer significant after further adjusted the BMI.
Conclusion BMI is the main influencing factor of the level of hs-CRP.The risk of developing MS increased with the level hs-CRP in women, but not in men.

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